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Epilim Chrono 500mg

Epilim Chrono 500mg

Availability: In Stock


Requires Doctor's Prescription

Treatment of generalised, partial or other epilepsy.

Therapeutic Class Antiepileptic
Side Effects The following CIOMS frequency rating is used, when applicable: Very common (≥ 1/10); common (≥ 1/100 to ≤ 1/10); uncommon (≥ 1/1,000 to ≤ 1/100); rare (≥ 1/10,000 to ≤ 1/1,000); very rare (≤ 1/10,000); not known (cannot be estimated from the available data).Congenital malformations and developmental disorders (see section 4.4 and section 4.6).Hepatobiliary disorders:Common: liver injury (see section 4.4.1 Warnings)Severe liver damage, including hepatic failure sometimes resulting in death, has been reported (see also sections 4.2, 4.3 and 4.4.1). Increased liver enzymes are common, particularly early in treatment, and may be transient (see section 4.4.1).Gastrointestinal disordersVery common: nauseaCommon: gastralgia, diarrhoeaThe above three adverse events frequently occur at the start of treatment, but they usually disappear after a few days without discontinuing treatment. These problems can usually be overcome by taking Epilim with or after food or by using Enteric Coated Epilim (Epilim Gastro-resistant tablets).Uncommon: pancreatitis, sometimes lethal (see section 4.4 Special Warnings and Special Precautions for Use)Nervous system disorders:Very common: tremorCommon: extrapyramidal disorder, stupor*, somnolence, convulsion*, memory impairment, headache, nystagmusUncommon: coma*, encephalopathy, lethargy* (see below), reversible parkinsonism, ataxia, paresthesia, aggravated convulsions (see section 4.4)Rare: reversible dementia associated with reversible cerebral atrophy, cognitive disorder
Active liver disease• Personal or family history of severe hepatic dysfunction, especially drug related• Patients with known urea cycle disorders (see section 4.4).• Hypersensitivity to sodium valproate• Porphyria• Valproate is contraindicated in patients known to have mitochondrial disorders caused by mutations in the nuclear gene encoding the mitochondrial enzyme polymerase γ (POLG), e.g. Alpers-Huttenlocher Syndrome, and in children under two years of age who are suspected of having a POLG-related disorder (see section 4.4).
4.4 Special warnings and precautions for use
Although there is no specific evidence of sudden recurrence of underlying symptoms following withdrawal of valproate, discontinuation should normally only be done under the supervision of a specialist in a gradual manner. This is due to the possibility of sudden alterations in plasma concentrations giving rise to a recurrence of symptoms. NICE has advised that generic switching of valproate preparations is not normally recommended due to the clinical implications of possible variations in plasma concentrations.

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