▶Common or very common Abdominal pain . constipation .
diarrhoea . dizziness . dyspepsia . haemorrhage . headache .
hypotension . nausea . pain in extremities . pruritus . rash .
renal impairment . vomiting
▶ Uncommon Angioedema . dry mouth . malaise . syncope .
tachycardia . thrombocythaemia
▶ Rare Jaundice . oedema
Active bleeding . in acute coronary
syndrome—previous stroke . in acute coronary syndrome—
transient ischaemic attack . malignant neoplasms .
oesophageal varices . recent brain surgery . recent gastrointestinal
ulcer . recent intracranial haemorrhage . recent
ophthalmic surgery . recent spine surgery . significant risk
of major bleeding . vascular aneurysm
|Dosage||Prophylaxis of venous thromboembolism following knee replacement surgery ▶ BY MOUTH ▶ Adult: 10 mg once daily for 2 weeks, to be started 6–10 hours after surgery Prophylaxis of venous thromboembolism following hip replacement surgery ▶ BY MOUTH ▶ Adult: 10 mg once daily for 5 weeks, to be started 6–10 hours after surgery Initial treatment of deep-vein thrombosis | Initial treatment of pulmonary embolism ▶ BY MOUTH ▶ Adult: Initially 15 mg twice daily for 21 days, to be taken with food Continued treatment of deep-vein thrombosis (following initial treatment) | Continued treatment of pulmonary embolism (following initial treatment) | Prophylaxis of recurrent deep-vein thrombosis | Prophylaxis of recurrent pulmonary embolism ▶ BY MOUTH ▶ Adult: 20 mg once daily, to be taken with food Prophylaxis of stroke and systemic embolism in patients with non-valvular atrial fibrillation and with at least one of the following risk factors: congestive heart failure, hypertension, previous stroke or transient ischaemic attack, age 75 years, or diabetes mellitus ▶ BY MOUTH ▶ Adult: 20 mg once daily, to be taken with food Prophylaxis of atherothrombotic events following an acute coronary syndrome with elevated cardiac biomarkers (in combination with aspirin alone or aspirin and clopidogrel) ▶ BY MOUTH ▶ Adult: 2.5 mg twice daily usual duration 12 months|
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